\u0130zmir Ekonomi \u00dcniversitesi (\u0130E\u00dc) bakterilere kar\u015f\u0131 yeni antibiyotikler geli\u015ftirilmesi i\u00e7in harekete ge\u00e7erek baktetilere kar\u015f\u0131 sava\u015f a\u00e7t\u0131.<\/p>\n
\u0130zmir Ekonomi \u00dcniversitesi (\u0130E\u00dc) bakterilere kar\u015f\u0131 yeni antibiyotikler geli\u015ftirilmesi i\u00e7in bir \u00e7al\u0131\u015fma ba\u015flatarak yeni bir d\u00f6neme girildi. Biyomedikal M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc Doktor \u00d6\u011fretim \u00dcyesi Osman Doluca, T\u00dcB\u0130TAK 3501 proje deste\u011fiyle daha \u00f6nce E.coli bakterisinin DNA\u2019s\u0131nda ke\u015ffettikleri anahtar yap\u0131n\u0131n g\u00f6revlerini ortaya \u00e7\u0131karaca\u011f\u0131n\u0131 belirtti. Doluca, b\u00f6ylece zararl\u0131 bakterilerle m\u00fccadelede yeni kap\u0131n\u0131n aralanaca\u011f\u0131n\u0131 ifade ederek, bakterilere kar\u015f\u0131 yeni antibiyotiklerin geli\u015ftirilme \u00e7al\u0131\u015fmalar\u0131na \u0131\u015f\u0131k olaca\u011f\u0131 belirtildi.<\/p>\n
E.coli bakterisinin DNA\u2019s\u0131nda buldu\u011fu anahtar yap\u0131n\u0131n potasyum ya da magnezyum fazlal\u0131\u011f\u0131na ba\u011fl\u0131 olarak de\u011fi\u015febildi\u011fini belirlediklerini kaydeden Doluca, “\u015eimdi de bu yap\u0131n\u0131n g\u00f6revini inceleyece\u011fiz. Bakterinin b\u00fct\u00fcn gen yap\u0131s\u0131n\u0131 analiz ettik. Bakterinin DNA yap\u0131s\u0131nda G4\u2019l\u00fcs\u00fc dedi\u011fimiz 4 zincirli DNA ya da k\u00f6k ilmik yap\u0131s\u0131 bulunuyor. Bu yap\u0131n\u0131n ortamdaki tuz \u00e7e\u015fidi ve miktar\u0131na ba\u011fl\u0131 olarak de\u011fi\u015febildi\u011fini g\u00f6sterdik. E.coli bakterisinde 26 anahtar var. Hen\u00fcz bunlar\u0131n hepsinin \u00e7al\u0131\u015fma prensipleri bilinmiyor. Genlerin \u00e7al\u0131\u015fmas\u0131n\u0131 kontrol edebildi\u011fini d\u00fc\u015f\u00fcn\u00fcyoruz. E\u011fer \u00e7al\u0131\u015fma prensiplerini ortaya \u00e7\u0131karabilirsek bakterilere kar\u015f\u0131 yeni antibiyotik geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131na \u0131\u015f\u0131k olabilecek” dedi.<\/p>\n
Her h\u00fccrede kontrol sisteminin bulundu\u011funu belirten Doluca, daha \u00f6nce bilgisayar yard\u0131m\u0131yla (biyoenformatik) ke\u015ffettikleri korunmu\u015f bir G-d\u00f6rtl\u00fcs\u00fcn\u00fcn biyolojik rol\u00fcn\u00fc ortaya \u00e7\u0131karmak i\u00e7in T\u00dcB\u0130TAK\u2019tan destek ald\u0131klar\u0131n\u0131 s\u00f6yledi. Bu \u00e7al\u0131\u015fmayla yap\u0131n\u0131n rol\u00fcn\u00fc, h\u00fccredeki de\u011fi\u015fimi inceleyeceklerini aktaran Doluca, “Bakterilerin neden oldu\u011fu hastal\u0131klarla m\u00fccadelede kullan\u0131lan ila\u00e7lar\u0131n geli\u015fmesi i\u00e7in yeni y\u00f6ntemler ortaya koymay\u0131 hedefliyoruz diye konu\u015ftu.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u0130ZM\u0130R EKONOM\u0130 \u00dcN\u0130VERS\u0130TES\u0130 (\u0130E\u00dc) BAKTER\u0130LERE KAR\u015eI YEN\u0130 ANT\u0130B\u0130YOT\u0130KLER GEL\u0130\u015eT\u0130R\u0130LMES\u0130 \u0130\u00c7\u0130N HAREKETE GE\u00c7T\u0130. B\u0130YOMED\u0130KAL M\u00dcHEND\u0130SL\u0130\u011e\u0130 B\u00d6L\u00dcM\u00dc DOKTOR \u00d6\u011eRET\u0130M \u00dcYES\u0130 OSMAN DOLUCA, \u00c7ALI\u015eMALAR HAKKINDA B\u0130LG\u0130 VERD\u0130.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,20],"tags":[25510,105044,44729,50496,15443,1594],"class_list":["post-1260323","post","type-post","status-publish","format-standard","hentry","category-saglik","category-turkiye","tag-acacak","tag-bakterilere","tag-bulus","tag-cigir","tag-karsi","tag-yeni"],"_links":{"self":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts\/1260323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1260323"}],"version-history":[{"count":0,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts\/1260323\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1260323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1260323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1260323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}