![\"\"\/](\"https:\/\/cdn.iha.com.tr\/Contents\/pool_file\/2021\/39\/12575_aw428373-02.jpg\")
<\/figure>\n\n\n\n2 doz Sinovac + 1 doz Biontech a\u015f\u0131s\u0131 uygulanan ki\u015filerin antikor koruyuculuk de\u011ferleri \u00fcst\u00fcnl\u00fck g\u00f6sterdi<\/strong><\/p>\n\n\n\n Ayr\u0131ca 3 doz Sinovac uygulanan 61 ki\u015fide yan etki ya\u015fama s\u0131kl\u0131\u011f\u0131 y\u00fczde 45.9’ken en s\u0131k yan etkiler y\u00fczde 29.5 enjeksiyon b\u00f6lgesinde a\u011fr\u0131 ve y\u00fczde 14.8 yorgunluk olarak tespit edildi. Antikor d\u00fczeylerinde ise ortalama antikor de\u011feri 32.41 ile 42.34 (min:1.36, maks:150) olarak g\u00f6r\u00fcld\u00fc. Bu ki\u015filerin t\u00fcm\u00fcnde antikor d\u00fczeyleri 1.0’in \u00fcst\u00fcndeyken; y\u00fczde 34.4’\u00fcnde antikor d\u00fczeyleri 1.0-10.0 aras\u0131nda, y\u00fczde 57.4’\u00fcnde 10.0-150 aras\u0131nda ve y\u00fczde 8.2’sinde ise 150’nin \u00fcst\u00fcnde oldu\u011fu tespit edildi.<\/p>\n\n\n\n 2 doz Sinovac + 1 doz Biontech uygulanan 416 ki\u015finin bulgular\u0131na bak\u0131ld\u0131\u011f\u0131nda ise; yan etki ya\u015fama s\u0131kl\u0131\u011f\u0131 y\u00fczde 80.3’ken en s\u0131k yan etkiler y\u00fczde 66.6 enjeksiyon b\u00f6lgesinde a\u011fr\u0131, y\u00fczde 35.8 yorgunluk ve y\u00fczde 21.9 ba\u015f a\u011fr\u0131 oldu\u011fu tespit edildi. Ortalama antikor de\u011feri 145.14 ile 23.13 (min:0, maks:150) oldu\u011fu g\u00f6r\u00fclen \u00e7al\u0131\u015fmalarda; gruptakilerin y\u00fczde 0.5’inde antikor d\u00fczeyleri 1.0’\u0131n alt\u0131nda, y\u00fczde 0.7’sinde 1-10 aras\u0131nda; y\u00fczde 3.8’inde 10-150 aras\u0131nda ve y\u00fczde 95’inde ise 150’nin \u00fcst\u00fcnde oldu\u011fu g\u00f6r\u00fcld\u00fc.<\/p>\n\n\n\n Sadece 2 doz Sinovac uygulanan 43 ki\u015finin 6. ay antikor d\u00fczeylerine bak\u0131ld\u0131\u011f\u0131nda antikor d\u00fczeyleri ortalamas\u0131 25.61 ile 52.68 (min:0, maks:150) oldu\u011fu tespit edildi. Kat\u0131l\u0131mc\u0131lar\u0131n y\u00fczde 44.2’sinde antikor d\u00fczeyi 1.0’\u0131n alt\u0131nda (yetersiz), y\u00fczde 32.5’inde 1.0-10.0 aras\u0131nda, y\u00fczde 23.3’\u00fcnde 10.0’\u0131n \u00fczerinde oldu\u011fu bilgisi verilen \u00e7al\u0131\u015fmada 43 ki\u015finin antikor d\u00fczeyi 10.0’\u0131n \u00fczerinde olan ki\u015filerin tamam\u0131n\u0131n korona vir\u00fcs ge\u00e7mi\u015fi oldu\u011fu belirlendi. Daha \u00f6nceki \u00e7al\u0131\u015fmalarda 2 doz Sinovac a\u015f\u0131 uygulamas\u0131ndan 1 ve 3 ay sonra etkili antikor d\u00fczeyleri s\u0131ras\u0131yla y\u00fczde 97 ve y\u00fczde 77 bulunmu\u015fken, bu \u00e7al\u0131\u015fmada 6. ayda y\u00fczde 55.8’e d\u00fc\u015ft\u00fc\u011f\u00fc saptand\u0131.<\/p>\n\n\n\n 3. doz a\u015f\u0131 olanlar\u0131n hastal\u0131\u011fa yakalanma oran\u0131nda belirgin d\u00fc\u015f\u00fc\u015f<\/strong><\/p>\n\n\n\n Eksik ya da tam a\u015f\u0131l\u0131lar\u0131n ger\u00e7ek ya\u015fam bulgular\u0131na bak\u0131ld\u0131\u011f\u0131nda; toplam 1982 \u00e7al\u0131\u015fan\u0131n 1968\u2018inin sonu\u00e7lar\u0131 de\u011ferlendirildi. 1 Temmuz- 24 Eyl\u00fcl 2021 tarihleri aras\u0131nda hastanede 44 ki\u015finin hastal\u0131\u011fa yakaland\u0131\u011f\u0131; y\u00fczde 20.4′ \u00fcn\u00fcn a\u015f\u0131s\u0131z ya da eksik (tek doz Sinovac ya da tek doz Biontech) a\u015f\u0131l\u0131 oldu\u011fu anla\u015f\u0131ld\u0131. A\u015f\u0131s\u0131z ya da eksik a\u015f\u0131l\u0131 olma y\u00fczdesi doktorlarda y\u00fczde 5, hem\u015firelerde y\u00fczde 21.3, di\u011fer hastane \u00e7al\u0131\u015fanlar\u0131nda ise y\u00fczde 14.2. Ayr\u0131ca a\u015f\u0131s\u0131z ve eksik a\u015f\u0131s\u0131 (tek doz Sinovac veya tek doz Biontech) olan 257 \u00e7al\u0131\u015fanda Covid-19’a yakalanma s\u0131kl\u0131\u011f\u0131 y\u00fczde 3.5, sadece iki doz Sinovac a\u015f\u0131s\u0131 olan 352 ki\u015fide y\u00fczde 6.25, sadece iki doz Biontech a\u015f\u0131s\u0131 olan 115 ki\u015fide y\u00fczde 1.74, \u00fc\u00e7 doz Sinovac a\u015f\u0131s\u0131 olan 130 ki\u015fide y\u00fczde 3.84, iki doz Sinovac + 1 doz Biontech a\u015f\u0131s\u0131 olan 902 ki\u015fide y\u00fczde 0.67 oldu\u011fu tespit edildi.<\/p>\n\n\n\n \u201c3. doz a\u015f\u0131da uygulanan Biontech a\u015f\u0131s\u0131, 3. doz Sinovac a\u015f\u0131s\u0131na g\u00f6re koruyuculukta belirgin \u00fcst\u00fcnl\u00fck g\u00f6stermi\u015ftir\u201d<\/strong><\/p>\n\n\n\n Ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131 ise \u015fu \u015fekilde payla\u015f\u0131ld\u0131:<\/strong><\/p>\n\n\n\n “A\u015f\u0131s\u0131z ya da eksik a\u015f\u0131l\u0131 olma y\u00fczdesi beklenenin \u00fcst\u00fcndedir. \u00d6zellikle yakla\u015f\u0131k 5 hem\u015fireden birisi a\u015f\u0131s\u0131z ya da eksik a\u015f\u0131l\u0131d\u0131r. Sadece 2 doz Sinovac olanlarda antikor koruyuculuk d\u00fczeyi, ikinci a\u015f\u0131dan sonra \u00fc\u00e7\u00fcnc\u00fc ayda y\u00fczde 56’ya d\u00fc\u015fm\u00fc\u015ft\u00fcr. Bu veri 3. doz a\u015f\u0131laman\u0131n yerinde bir karar oldu\u011funu kan\u0131tlam\u0131\u015ft\u0131r. 3. doz a\u015f\u0131 tercihi ne olursa olsun, 3 doz a\u015f\u0131y\u0131 olan bireylerin t\u00fcm\u00fc koruyucu antikor d\u00fczeylerine ula\u015fm\u0131\u015flard\u0131r. 3. doz a\u015f\u0131da uygulanan Biontech a\u015f\u0131s\u0131, \u00fc\u00e7\u00fcnc\u00fc doz Sinovac a\u015f\u0131s\u0131na g\u00f6re koruyuculukta (gerek antikor d\u00fczeyi, gerekse hastalanma durumu a\u00e7\u0131s\u0131ndan) belirgin \u00fcst\u00fcnl\u00fck g\u00f6stermi\u015ftir.<\/p>\n\n\n\n 3. dozu Biontech olanlar\u0131n antikor d\u00fczeyi, kat\u0131l\u0131mc\u0131lar\u0131n y\u00fczde 95’inde \u00f6l\u00e7\u00fclebilen maksimum titrenin \u00fcst\u00fcndedir. Bu durumda 2 doz Sinovac + 1 doz Biontech sonras\u0131 4. doz Biontech a\u015f\u0131s\u0131 uygulanmas\u0131n\u0131n hen\u00fcz erken oldu\u011fu d\u00fc\u015f\u00fcn\u00fclebilir. Olas\u0131 2. doz Biontech a\u015f\u0131s\u0131n\u0131n (4. dozun) ne zaman yap\u0131lmas\u0131 gerekti\u011fi sorusuna, 3. doz uygulamas\u0131 sonras\u0131 3. ve 6. ay sonu\u00e7lar\u0131 elde edildi\u011finde yan\u0131t verilebilir. \u0130ster eksik a\u015f\u0131l\u0131, ister tam a\u015f\u0131l\u0131 olsun 3. a\u015f\u0131dan sonra ge\u00e7en d\u00f6nemde hastalanan 44 \u00e7al\u0131\u015fandan hi\u00e7biri hastaneye yat\u0131r\u0131lmam\u0131\u015f, hastal\u0131\u011f\u0131 ayakta ge\u00e7irmi\u015flerdir.”<\/p>\n\n\n\n Ara\u015ft\u0131rma ekibinde ise \u015fu isimler yer ald\u0131:<\/strong><\/p>\n\n\n\n “Manisa CB\u00dc T\u0131p Fak\u00fcltesi T\u0131bbi Mikrobiyoloji Anabilim Dal\u0131 \u00dcyesi Prof. Dr. Sinem Ak\u00e7al\u0131, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Prof. Dr. Erhan Eser, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Prof. Dr. P\u0131nar Erbay D\u00fcndar, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Prof. Dr. Beyhan Cengiz \u00d6zyurt, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Enfeksiyon Hastal\u0131klar\u0131 Anabilim Dal\u0131 Dr. \u00d6\u011fr. \u00dcyesi \u015eebnem \u015eenol Akar, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Enfeksiyon Hastal\u0131klar\u0131 Anabilim Dal\u0131 Dr. \u00d6\u011fr. G\u00f6r. Deniz \u00d6zer, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Dr. Yunus \u00d6zkaya, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Dr. K\u00fcbra \u00c7i\u00e7ek, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Dr. Zeynep \u00d6yk\u00fc \u00d6zt\u00fcrk Ar\u0131kan, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Halk Sa\u011fl\u0131\u011f\u0131 Anabilim Dal\u0131 \u00dcyesi Dr. Zeynep Ceyda Buran, Manisa CB\u00dc T\u0131p Fak\u00fcltesi Hastanesi Uz. Hem\u015fire Ferya Karada\u011f Yal\u00e7\u0131n.”<\/p>\n","protected":false},"excerpt":{"rendered":" Manisa Celal Bayar \u00dcniversitesi (MCB\u00dc) T\u0131p Fak\u00fcltesi Enfeksiyon Hastal\u0131klar\u0131, Halk Sa\u011fl\u0131\u011f\u0131 ve T\u0131bbi Mikrobiyoloji Anabilim Dal\u0131 \u00f6\u011fretim elemanlar\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclen ‘Kar\u015f\u0131la\u015fmal\u0131 3 Doz Covid-19 A\u015f\u0131 (Sinovac ya da Biontech) Etkililik Sonu\u00e7lar\u0131 2 Doz Sinovac Sonras\u0131 6. Ay Takip Sonu\u00e7lar\u0131’na g\u00f6re, 2 doz Sinovac olanlarda \u00fc\u00e7\u00fcnc\u00fc aydan sonra antikor oran\u0131 y\u00fczde 56\u2019ya d\u00fc\u015ferken, 3. doz a\u015f\u0131laman\u0131n […]<\/p>\n","protected":false},"author":1,"featured_media":1573496,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1573495","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem"],"_links":{"self":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts\/1573495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1573495"}],"version-history":[{"count":0,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/posts\/1573495\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=\/wp\/v2\/media\/1573496"}],"wp:attachment":[{"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1573495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1573495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.erzhaber.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1573495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"\/](\"https:\/\/cdn.iha.com.tr\/Contents\/pool_file\/2021\/39\/2861_aw428373-04.jpg\")
<\/figure>\n\n\n\n![\"\"\/](\"https:\/\/cdn.iha.com.tr\/Contents\/pool_file\/2021\/39\/70437_aw428373-05.jpg\")
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